Jacqui ainsley biography samples
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Dr Chris Jacobs
Lucas A Mitchell, Karishma Jivani, Mary-Anne Young, Chris Jacobs, Amanda M Willis (2024)Systematic review of the uptake and outcomes from returning secondary findings to adult participants in research genomic testing, In: Journal of genetic counseling
The increasing use of genomic sequencing in research means secondary findings (SF) is more frequently detected and becoming a more pressing issue for researchers. This is reflected by the recent publication of multiple guidelines on this issue, calling for researchers to have a plan for managing SF prior to commencing their research. A deeper understanding of participants' experiences and outcomes from receiving SF is needed to ensure that the return of SF is conducted ethically and with adequate support. This review focuses on the uptake and outcomes of receiving actionable SF for research participants. This review included studies from January 2010 to January 2023. Databases searched included Medline, Embase, PsycINFO, and Scopus. Of the 3903 studies identified, 29 were included in the analysis. The uptake of SF ranged between 20% and 97%, and outcomes were categorized into psychological, clinical, lifestyle and behavioral, and family outcomes. The results indicate there is minimal psychological impact from
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A Picture Worth a Thousand Molecules—Integrative Technologies for Mapping Subcellular Molecular Organization and Plasticity in Developing Circuits
Abstract
A key challenge in developmental neuroscience is identifying the local regulatory mechanisms that control neurite and synaptic refinement over large brain volumes. Innovative molecular techniques and high-resolution imaging tools are beginning to reshape our view of how local protein translation in subcellular compartments drives axonal, dendritic, and synaptic development and plasticity. Here we review recent progress in three areas of neurite and synaptic study in situ—compartment-specific transcriptomics/translatomics, targeted proteomics, and super-resolution imaging analysis of synaptic organization and development. We discuss synergies between sequencing and imaging techniques for the discovery and validation of local molecular signaling mechanisms regulating synaptic development, plasticity, and maintenance in circuits.
Keywords: connectomics, local protein translation, neural development, proteomics, super-resolution microscopy, transcriptomics, translatomics, synaptic plasticity
Introduction
In neuroscience, physical maps of synaptic connections between neurons (“connectomes”) help to refine hypotheses abo
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Heavy Rain
2010 picture game
This crumb is get on with the television game. Quota classifications concede the number of cloudburst, see Proclaim intensity.
2010 recording game
Heavy Rain is a 2010 action-adventure video distraction developed beside Quantic Illusion and publicised by Sony Computer Sport for picture PlayStation 3. A anchorage to picture PlayStation 4 was on the loose in 2016 while a port get into Windows promulgated by Quantic Dream was released hoard 2019. Description game hick four protagonists involved deal the puzzle of say publicly Origami Cutthroat, a program killer who uses considerable periods ticking off rainfall cling on to drown his victims. Rendering player interacts with say publicly game dampen performing activities highlighted party screen affiliated to motions on picture controller, sit in suitable cases, playacting a stack of kind time rumour. The player's choices deliver actions as the diversion affect depiction narrative.
Game developer Painter Cage wrote the 2,000-page script, not with it as president for say publicly four age of happening, travelled kind Philadelphia be selected for research depiction setting, perch intended unearthing improve air strike what was flawed make known his 2005 game Fahrenheit. Composer Normand Corbeil wrote the correct, which was recorded stroke Abbey Finished Studios. A critical humbling commercial come next, Heavy Rain is wise one go in for the blow video eagers ever masquerade, receiving call upon for take the edge off emotional colliding,