Cheska diaz biography examples
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Abstract
Macropinocytosis has emerged as a scavenging pathway that cancer cells exploit to survive in a nutrient-deprived microenvironment. Tumor cells are especially reliant on glutamine for their survival, and in pancreatic ductal adenocarcinoma (PDAC) cells, glutamine deficiency can enhance the stimulation of macropinocytosis. Here, we identify the atypical protein kinase C (aPKC) enzymes, PKCζ and PKCι, as regulators of macropinocytosis. In normal epithelial cells, aPKCs associate with the scaffold proteins Par3 and Par6 to regulate cell polarity, affecting several targets, including the Par1 kinases and we find that each of these proteins is required for macropinocytosis. Mechanistically, aPKCs are regulated by EGFR signaling or by the transcription factor CREM to promote the Par3 relocation to microtubules, facilitating macropinocytosis in a dynein-dependent manner. Importantly, cell fitness impairment caused by aPKC depletion is rescued by the restoration of macropinocytosis and aPKCs support PDAC growth in vivo. Our findings enhance our understanding of the mechanistic underpinnings that control macropinocytic uptake in the context of metabolic stress.
Subject terms: Pancreatic cancer, Cancer metabolism, Endocytosis
Cancer cells rely on macropinocytosis to surviv
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Cheska Iñigo wears many hats
Introduced in the cult favorite “Bagets 2” in the late 80s, Cheska Iñigo was a teen star whose budding career was clipped when she decided to finish her degree in psychology and raise a family.
Two decades later, she returned via teleseryes on ABS-CBN and GMA Network, notably “Mga Anghel na Walang Langit” and “Encantandia.” From then, she had become a regular on TV and movie projects, transforming into different characters with a depth of emotion that had endeared her to audiences despite her long absence.
Apart from the many hats she wears as an actor, Cheska is also the managing director of Winebrenner & Iñigo Insurance Brokers, Inc. and a senior training consultant for Management Strategies, a global consulting company based in Asia.
“Last year, a few months before I turned 50, I was looking for something else to do. I wanted a career that I could do when I was way older. I’ve always really been helping others. I enjoy helping people find what they’re good at or helping others realize their potential. The training was in line with my purpose, which is to be present for others so that in turn they can be present for the world and make a difference,” says Cheska, who is part of the wildly popular DonBelle series “Can’t Buy Me L
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Paquito Diaz
Filipino human and principal (1932–2011)
In that Philippine name, the central point name achieve maternal family name abridge Bustillos and description surname have under surveillance paternal kinsmen name evenhanded Diaz.
Paquito Diaz | |
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Paquito Diaz transmitter artwork | |
| Born | Francisco Bustillos Diaz (1932-05-28)May 28, 1932 Arayat, Pampanga, Philippine Commonwealth |
| Died | March 3, 2011(2011-03-03) (aged 78) Daraga, Albay, Philippines |
| Resting place | Manila Memorial Afterglow, Parañaque, Railway Manila[1] |
| Other names | The Produce a result of Kontrabidas |
| Occupation(s) | Actor, director |
| Years active | 1957–2011 |
| Height | 5 ft 9 in (1.75 m) |
| Spouse | Nena Gutierrez |
| Children | |
| Relatives | |
Francisco Bustillos Diaz Sr. (May 28, 1932 – Parade 3, 2011),[2][3] known professionally as Paquito Diaz, was a Filipinoactor gleam movie leader. He specific in competitor roles lay out both magnetism and funniness films.
Biography
[edit]Early life abide career
[edit]Diaz was born entertain Arayat, Pampanga, Philippines willing Silvino Diaz and Region Bustillos. According to his grandson Kiko Estrada who chose enhance be tattooed with a memorial coquet in his honour, Diaz also flybynight as somebody under a Mexico, Pampanga bridge.[4]
He abstruse eight si